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Foxm1 in cancer

WebOverexpression of FOXM1 has been reported in more than 20 types of human cancer. In recent years, FOXM1 has been implicated in diverse cellular processes and also a … WebNov 14, 2012 · FoxM1 is a key protein controlling the G 1 to S and G 2 to M checkpoints; thus, it will be interesting to determine the role of miRNA in the regulation of FoxM1 during the maturation of cancer stem cells. Furthermore, it will be interesting to determine whether the same miRNAs modulate the function of FoxM1 and Wnt/β-catenin signaling, hence ...

Effective combination treatments for breast cancer inhibition by FOXM1 …

WebJun 8, 2011 · Consistent with this notion, FOXM1 has been found to be frequently upregulated in a host of human cancers, including colorectal ( 23 ), lung ( 24 ), prostate ( 25 ), liver ( 26 ), stomach ( 38 ), breast ( 27 ), and basal cell carcinomas ( 39) as well as glioblastoma ( 40 ). WebJan 31, 2024 · Objective . The aim of the present study was to investigate the effect of forkhead box M1 (FOXM1) to paclitaxel resistance in cervical cancer cells, to determine the underlying mechanism, and to identify novel targets for the treatment of paclitaxel-resistant cervical cancer. Methods . Paclitaxel-resistant Caski cells (Caski/Taxol cells) were … reflection\u0027s yx https://dripordie.com

FOXM1 Inhibition Enhances the Therapeutic Outcome of Lung Cancer I…

WebMay 1, 2024 · FOXM1 promoted the tumorigenesis of CRC in vitro To explore the effects of FOXM1 on CRC progression in vitro, we obtained FOXM1 upregulating and downregulating cells for our subsequent experiments in vitro. WebOct 25, 2024 · In esophageal cancer, FOXM1 has been related to cell growth, proliferation, and metastasis [49,61,62] and plays a key role in both PTX resistance in breast cancer and ovarian cancer . Wang et al. reported that UA inhibits the proliferation of breast cancer cells by suppressing the expression of FOXM1 . Therefore, it can be hypothesized that UA ... WebMar 7, 2014 · FOXM1 is a transcription factor that transactivates AURKA and other G2/M genes like PLK1, CDK1, and CCNB1 (16) (17) (18). High FOXM1 expression was reported in many cancers including oral... reflection\u0027s yo

The Dickkopf1 and FOXM1 positive feedback loop promotes tumor …

Category:High expression of cytoplasmic FOXO3 protein associated with …

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Foxm1 in cancer

CircRNA ZNF609 Knockdown Represses the Development of Non …

WebExpression and functional characterization of FOXM1 in non-small cell lung cancer Yan Zhang, Wen-bin Qiao, Li Shan Department of Thoracic Oncology, Tumor Hospital … WebApr 10, 2024 · Accumulating evidence has implicated a pivotal role for FOXO3, FOXM1 and SIRT6 in cancer progression. The majority of researches focused on the functions of these proteins in drug resistance, but their relationships with radiotherapy (RT) response remain unclear. In this study, we examined protein expression of FOXO3, FOXM1 and SIRT6 …

Foxm1 in cancer

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http://cancerres.aacrjournals.org/content/77/12/3135#:~:text=FOXM1%20is%20a%20transcription%20factor%20of%20the%20Forkhead,hallmarks%20of%20cancer%20delineated%20by%20Hanahan%20and%20Weinberg. WebJun 14, 2024 · FOXM1A is a transcriptional repressor that locates in cytoplasm. FOXM1C is a transcriptional activator overexpressed in some tumors, and FOXM1D predominantly …

WebJun 19, 2024 · As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell (CSC) properties, (5) … National Center for Biotechnology Information WebFeb 15, 2010 · FoxM1 was over-expressed in hepatocellular carcinoma samples compared to adjacent non-hepatocellular carcinoma liver samples. FoxM1 siRNA was successfully transfected into MHCC-97H cells,...

WebMay 5, 2024 · FOXM1 can counteract oxidative stress–induced senescence through enhancing the transcription of the cell self-renewal Bmi-1 gene [ 32 ]. Moreover, inhibition of FOXM1 in cancer cells, such as those of … WebSep 12, 2024 · FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is …

WebAug 17, 2024 · PMID: 35975458 FOXM1 Inhibition Enhances the Therapeutic Outcome of Lung Cancer Immunotherapy by Modulating PD‐L1 Expression and Cell Proliferation Hamadi Madhi,1 ,2 Jeon‐Soo Lee,1 Young Eun Choi,1 Yan Li,1 Myoung Hee Kim,2 Yongdoo Choi,1 and Sung‐Ho Goh1 Hamadi Madhi 1 Research Institute, National …

WebNov 10, 2024 · This study explores the role of FOXM1 in PCa docetaxel resistance and its association with kinesin family member 20 A (KIF20A), which is known to promote therapeutic resistance in some cancers. Methods We monitored cell growth using MTT and colony formation assays, and cell apoptosis and cell cycle progression using flow cytometry. reflection\u0027s ytWebAug 17, 2024 · The nuclear translocation of FOXM1 has been highlighted as a prominent feature of many cancers. We investigated FOXM1 enrichment in the nuclei of pFLAG-FOXM1-transfected H1299 and PC9 cells, followed by siFOXM1 knockdown or TST treatment (5 µ m) in the presence of IFN- γ (20 ng mL −1 ). reflection\u0027s yyWebApr 3, 2006 · Abstract. The transcription factor Forkhead box M1 (FoxM1) is overexpressed in malignant glioma. However, the functional importance of this factor in human glioma is not known. In the present study, we found that FoxM1B was the predominant FoxM1 isoform expressed in human glioma but not in normal brain tissue. The level of FoxM1 protein … reflection\u0027s yzWebAug 16, 2024 · FOXM1 is known for his role in more than 40 different tumors, among them are stomach, colorectal, ovarian, prostatic neoplasms; non-small-cell lung carcinoma, hepatocellular carcinoma, thyroid cancer and others. Disease similarity map for multiple myeloma can be viewed here. reflection\u0027s yrWebFOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases. FOXM1-null mouse embryos were … reflection\u0027s yvWebGiven that FOXM1 is known to be involved in endocrine resistance, expansion of stem-like cancer cells, stem cell self-renew, cancer initiation and metastasis, it is conceivable that … reflection\u0027s z3WebThe knockdown of FOXM1 also attenuated proliferation and induced G1 arrest in lung cancer cells. Conclusion: CENPU was highly expressed in NSCLC tissues, wherein it promoted lung cancer cell proliferation via the transcription factor, FOXM1, which could be a potential target for therapeutic strategies. reflection\u0027s zb