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Plectin网蛋白

Webb15 apr. 2008 · As an in vivo screening approach, we have used phage as targeted nanoparticles for imaging by labeling the phage coat proteins with a near infrared fluorochrome [ 21, 27 ]. The Cy5.5-labeled phage were injected IV 4 h prior to imaging for both the distribution and tumor imaging studies. Webb19 sep. 2024 · Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.The most common disorder is autosomal recessive disease epidermolysis bullosa simplex with muscular dystrophy …

半桥粒与基底膜带 - 皮肤病学 - 天山医学院

WebbPlectin antibody detects Plectin protein at cytoskeleton by immunofluorescent analysis. Sample: U2OS cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Plectin stained by Plectin antibody (GTX130764) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at … Webb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by … margohelp.pl https://dripordie.com

PLEC Gene - Altmeyers Encyclopedia - Department Dermatology

Webb12 nov. 2024 · 经蛋白组学分析，靶向肽PTP是通过与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用的。 然而，胰腺癌在遗传上是非常复杂的，肿瘤的质量是由患者的63个基因改变和12个核心信号通路的异常引起的，在不同癌症患者的肿瘤生物标志物表达中存在异质性。 Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin pl… WebbPlectin基因敲除抑制了每个器官的转移数量，并降低了整体转移负担。 为了深入了解plectin在前列腺癌生长和转移中的作用，研究人员对前列腺癌plectin敲除异种移植组织进行了蛋白质组学分析。 基因集富集分析表明，与细胞外基质和层粘连蛋白相互作用有关的蛋白质水平增加，而调节氨基酸代谢、细胞骨架蛋白和细胞应激反应蛋白质水平下降。 … margo hemingway measurements

Plectin ensures intestinal epithelial integrity and protects …

Category:PLEC plectin [Homo sapiens (human)] - Gene - NCBI

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Plectin网蛋白

半桥粒与基底膜带 - 皮肤病学 - 天山医学院

Webb为赋予胰腺癌细胞的亲和能力，将马来酰亚胺末端修饰的DSPE-PEG2k与胰腺癌细胞表面受体plectin-1靶向的多肽相连合成DSPE-PEG2k-PTP。 通过共组装的方式把LA-GEM前药、DSPE-PEG2k、DSPE-PEG2k-PTP注射到生理盐水中可制备粒径合适、分布均一的靶向纳米制 … Webb26 nov. 2024 · 后基于胰腺癌高特异性表面分子标志物 (plectin-1)，构建高效靶向性自组装多肽纳米载体，靶向递送DNA单链损伤修复抑制剂Olaparib和DNA双链损伤修复抑制剂JQ1（如图3） [6]。 图3 JQ1的“诱捕”与“杀伤”的策略 ♦ DNA折纸技术（详细内容在最后一部分） 2 纳米技术及应用国家工程研究中心 [7] 纳米技术及应用国家工程研究中心是我国 …

Plectin网蛋白

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WebbIdentified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Interacts with COL17A1 (PubMed:12482924). 功能: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such … WebbPlectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in …

WebbLa plectine (dite large cytolinker) est une plakine ( protéine de structure qui lie les membranes cellulaires aux filaments intermédiaires du squelette des cellules 1, aux filaments d' actine, microtubules, et filaments intermédiaires de vimentine). Rôles [ modifier modifier le code] Webb我们确定细胞连接蛋白Plectin是Src的伙伴，并在破骨细胞中组织肌动蛋白环的形成[13]。Plectin在大脑、心脏、骨骼肌和TRAP（+）MNC中高度表达[13,14,18,19]。Plectin有13种异构体，它们之间的作用略有不同[18]。这表明，Plectin变体在每个组织中起着不同的作用。

Webbplectin expression or by expressing only rodless plectin variants, as demonstrated in EBS-MD skeletal muscles [22]. Plectin mutations in EBS-MD patients and their links on CNS abnormalities are described below in the chapter Plectin-related Pathologies of the Central Nervous System. 2. Plectin in the Central Nervous System WebbRESEARCH PAPER Plectin deficiency in liver cancer cells promotes cell migration and sensitivity to sorafenib treatment Chiung-Chi Chenga, Wei-Ting Chao b, Chen-Chun Liao , Yu-Hui Tsengb, Yen-Chang Clark Laic, Yih-Shyong Laid, Yung-Hsiang Hsue, and Yi-Hsiang Liuf aDepartment of Pathology, Chang Bing Show Chwan Memorial Hospital, Lugang …

WebbThe cytolinker protein plectin anchors IF networks to junctional complexes, the nuclear envelope and cytoplasmic organelles and it mediates their cross talk with the actin and tubulin cytoskel-eton. These functions empower plectin to wield significant influence over IF network cytoarchitecture. Moreover, the unusual diversity of plectin isoforms

Webb16 maj 2024 · 2024年5月16日讯/生物谷BIOON/---选择性剪接（alternative splicing）是一种转录后调控机制，对转录组和蛋白质组的多样性至关重要。 通过增加蛋白水平的复杂性，选择性剪接可以引起细胞的功能变化。 众所周知，RNA结构元件在转录后调控过程（包括选择性剪接）中起着关键作用。 因此，由RNA二级结构编码的调节信息对选择性剪接决定的 … margo heightWebb5 mars 2024 · Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell … margo hemingway twitterWebb30 juni 2024 · 存储条件-20℃以下冰冻、干燥、避光。长期保存惰性（氩气或者氮气）保护。产品化学性质PTP-PEG-DSPE磷脂-聚乙二醇-胰腺癌靶向肽PTP与胰腺癌发生时误定位在细胞膜表面上的plectin-1特异性结合实现靶向作用。本产品仅用于研究和制造用途，不能用于人类或诊断用途。 margo henson seattleWebb5 feb. 2024 · These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. margo heitchueWebb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element … margo hepner hartWebbPlectin Plectin, also referred to as IFAP 300 or HD1, is a 500-kDa plakin family member. It is particularly important for hemidesmosome function in epithelial tissues, and as a … margo hemondWebbPlectin, a versatile cytoskeleton-associated protein of extraordinarily large size, is expressed abundantly in a wide variety of mammalian tissues and cell types. It is particularly prominent in stratified and simple epithelia, various types of muscle, and cells forming the blood–brain barrier ( Wiche 1989; Errante et al. 1994 ). margo hill eastern washington university