Spindle cell sarcoma with a fgfr1 fusion
WebFeb 14, 2024 · Abstract. Purpose: Altered FGFR1 signaling has emerged as a therapeutic target in epithelial malignancies. In contrast, the role of FGFR1 in soft-tissue sarcoma (STS) has not been established. Prompted by the detection and subsequent therapeutic inhibition of amplified FGFR1 in a patient with metastatic leiomyosarcoma, we investigated the … WebSep 9, 2024 · The tumor was resected with an initial diagnosis elsewhere of probable benign spindle cell tumor. The tumor locally recurred in 2 years and was excised again. The …
Spindle cell sarcoma with a fgfr1 fusion
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WebWith the growing availability of RNA sequencing technology in the pathology laboratory, new gene fusion-associated malignancies are increasingly being characterized.In this article, we describe the second ever reported case of a uterine sarcoma harboring a FGFR1-TACC1 gene fusion.The patient, a 53-yr-old perimenopausal woman, was found to have a 6 cm … WebFeb 12, 2024 · Neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasm is a recently described soft tissue tumor entity that occurs predominantly in …
Weband FGFR1-CAPRIN1 fusion which was detected by RNA panel sequencing. The fusion described above has not been proven in the literature so far. Overall, the tumor should … WebDec 1, 2024 · Histologically, this was a spindle cell neoplasm with coagulative necrosis, moderate cytologic atypia, and increased mitotic activity. By immunohistochemistry, the neoplastic cells coexpressed CD34 and S100, and lacked smooth muscle marker expression. RNA sequencing revealed the presence of a FGFR1-TACC1 gene fusion.
WebApr 9, 2024 · Cancer-associated inflammation has been established as a hallmark feature of almost all solid cancers. Tumor-extrinsic and intrinsic signaling pathways regulate the process of cancer-associated inflammation. Tumor-extrinsic inflammation is triggered by many factors, including infection, obesity, autoimmune disorders, and exposure to toxic … Weband FGFR1-CAPRIN1 fusion which was detected by RNA panel sequencing. The fusion described above has not been proven in the literature so far. Overall, the tumor should possibly be classi ed as a spindle-cell tumor with intermediate malignancy. Histology of the second surgery showed unchanged ndings. The distances of the 1.5 cm diameter …
WebFeb 21, 2024 · Summary of common FGFR alterations in brain tumors. Some alterations are strongly associated with low grade neuroepithelial lesions: FGFR1-TKD, FGFR1-TACC1 …
WebOct 13, 2024 · Immunohistochemically, there was a clear positivity for CD34 and FGFR1-CAPRIN1 fusion which was detected by RNA panel sequencing. The fusion described … chilly concentratoWebAs a very broad generalization, sarcomas with a spindle cell microscopic morphology occur in adults and are treated primarily with surgery and often adjuvant or neoadjuvant … gracshaw sirimWebJun 7, 2024 · The tumor was diagnosed as an unusual low grade spindle cell sarcoma with EWSR1-WT1 gene fusion. Four months after resection, physical examination and CT scans of the chest, abdomen, and pelvis ... gracre eventsWebpatients with FGFR1 amplification or FGFR fusion may benefit from FGFR targeted therapy which needs further clinical investigation. Keywords: FGFR1 amplification, FGFR fusion, … chilly cold coolWebDec 1, 2024 · NTRK fusion-positive uterine spindle cell sarcomas constitute a novel tumor type with features of fibrosarcoma; patients with these tumors may benefit from Trk … chilly come lets goWebDec 28, 2024 · Sarcoma is usually treated with surgery to remove the cancer. Other treatments might be used before or after surgery. Which treatments are best for you will … chilly cold clipartWebMar 1, 2015 · Interestingly, unlike the prototypical leukaemia‐inducing FGFR1 fusion genes, the FN1–FGFR1 chimeric protein was predicted to preserve its ligand‐binding domains, … chilly commune